Coccidioides by PCR

Casandra

Casandra Test Code AR09557Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 3016687CPT Codes 87798, 97916

Also known as: COCCI PCR

Clinical Use

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Use

The Coccidioides by PCR test is a qualitative assay designed to aid in the diagnosis of coccidioidomycosis, also known as Valley Fever. This infection is caused by the fungi Coccidioides immitis and Coccidioides posadasii. The test detects the presence of these fungi in respiratory samples, cerebrospinal fluid (CSF), and tissue specimens. This test serves as an adjunct to culture and serology but is not a replacement for these methods. Early detection and diagnosis are crucial for effective management and treatment of the disease, especially in regions where these fungi are endemic.

Special Instructions

Specimen source information is required at the time of submission for accurate processing and interpretation. It is important that tissue specimens are frozen immediately after collection to maintain integrity. Frozen transport conditions must be adhered to for all specimen types.

Limitations

While this PCR test is effective for detection, it does not distinguish between C. immitis and C. posadasii. Negative results do not rule out the presence of PCR inhibitors or nucleic acid concentrations below the detection level of the assay. Paraffin-embedded tissues and certain specimen types such as serum, plasma, and whole blood are not acceptable for this assay. The presence of inhibitors or improper storage can also affect the accuracy of results.

Test Details

New York Approved