Encephalitis Panel with Reflex to Herpes Simplex Virus Types 1 and 2 Glycoprotein G-Specific Antibodies, IgG, CSF (Change effective as of 08/19/24: Refer to 3017752 in the August Hotline)
Also known as: ENCEPHCSF
Use
Detects IgG antibodies in cerebrospinal fluid (CSF) against multiple viral pathogens associated with encephalitis, including West Nile virus, HSV 1/2, measles (rubeola), mumps, and varicella-zoster virus. Reflex testing to HSV‑1 and HSV‑2 glycoprotein‑G specific IgG is triggered when HSV 1 and/or 2 IgG screening is positive, enabling differentiation of HSV types 1 and 2.
Special Instructions
Laboratory Developed Test (LDT). Reflex testing to HSV‑1 G‑specific IgG and HSV‑2 G‑specific IgG will be added if HSV 1 and/or 2 IgG, CSF is ≥1.10 IV; additional charges apply.
Limitations
Not approved for use in New York State—NYDOH does not accept non‑permitted laboratory requests. Serum or plasma, contaminated, heat‑inactivated, or hemolyzed specimens are unacceptable. The test is semi‑quantitative and may yield equivocal results requiring repeat testing; false negatives early in infection or in low titer cases may occur.
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
Result Turnaround Time
4-6 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
5.0 mL (minimum 2.5 mL)
Minimum Volume
2.5 mL
Container
ARUP standard transport tube
Collection Instructions
Transfer 5.0 mL CSF to an ARUP standard transport tube.
Causes for Rejection
Serum or plasma; contaminated, heat‑inactivated, or hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient: 8 hours |
| Refrigerated | Refrigerated: 2 weeks |
| Frozen | Frozen: 1 month |
Other tests from different labs that may be relevant