FIB-4

Casandra

Casandra Test Code LC35995Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 403604CPT Codes 84450, 84460, 85049

Also known as: Cirrhosis, Liver Fibrosis, NAFLD, NASH

Clinical Use

Order Test

Use

FIB-4 index is reported to be a simple, accurate, non-invasive, and readily available laboratory test index that can help in evaluation of patients with HCV and Non-Alcoholic Fatty Liver Disease (NAFLD) for the presence of liver fibrosis indication for liver biopsy, and other liver-related complications. It was also reported to be concordant with FibroSure test results.

Special Instructions

The FIB-4 index value is derived using a formula involving age, AST, ALT, and platelet count. Special attention should be given to the correct interpretation of the index values as detailed in clinical studies. It has been reported to show high concordance with the FibroSure test in evaluating liver fibrosis. Analytical precision must be maintained to ensure accurate results.

Limitations

The test may produce falsely low platelet counts due to clumping or pseudothrombocytopenia caused by platelet satellitism. Falsely elevated counts can occur from RBC or WBC fragments, including fragmented leukemic cells and pseudoplatelets. Stability issues can also arise as the specimen is unstable when frozen or subjected to freeze/thaw cycles.

Test Details

Methodology

Automated Analyzer (Hematology)

Biomarkers

3 components

FIB-4 Index Calculation • HematologyAST and ALT Measurement • HematologyPlatelet Count • Hematology

LOINC Codes

Result Codes

1920-8
1742-6
777-3
98488-0

Result Turnaround Time

1 day

Specimen

Serum

Volume

1 mL

Minimum Volume

0.5 mL

Container

Gel-barrier tube or red-top tube

Collection Instructions

Separate serum or plasma from cells within 45 minutes of collection; invert EDTA tube immediately 8 to 10 times once tube is filled at time of collection.