FIB-4
Also known as: Cirrhosis, Liver Fibrosis, NAFLD, NASH
Use
FIB-4 index is reported to be a simple, accurate, non-invasive, and readily available laboratory test index that can help in evaluation of patients with HCV and Non-Alcoholic Fatty Liver Disease (NAFLD) for the presence of liver fibrosis indication for liver biopsy, and other liver-related complications. It was also reported to be concordant with FibroSure test results.
Special Instructions
Not provided.
Limitations
The test may produce falsely low platelet counts due to clumping or pseudothrombocytopenia caused by platelet satellitism. Falsely elevated counts can occur from RBC or WBC fragments, including fragmented leukemic cells and pseudoplatelets. Stability issues can also arise as the specimen is unstable when frozen or subjected to freeze/thaw cycles.
Methodology
Automated Analyzer (Hematology)
Biomarkers
LOINC Codes
- 1920-8 - AST SerPl-cCnc
- 1742-6 - ALT SerPl-cCnc
- 777-3 - Platelet # Bld Auto
- 98488-0 - Liver fibr score Ser Calc.FIB4
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Gel-barrier tube or red-top tube
Collection Instructions
Separate serum or plasma from cells within 45 minutes of collection; invert EDTA tube immediately 8 to 10 times once tube is filled at time of collection.
Causes for Rejection
Gross hemolysis; improper labeling
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 day |
| Refrigerated | 3 days |
| Frozen | Unstable |
Other tests from different labs that may be relevant