FISH, IGK‑BA 2p11.2
Also known as: IGK-BA, 2p11.2 Rearrangements, ALL, NHL, Lymphoma
Use
Translocations involving the immunoglobulin loci are recurring events in various subtypes of B‑cell lymphomas. In addition to translocations involving the IGH locus, variant translocations have been described in 5‑10% of B‑cell neoplasms involving either the immunoglobulin kappa (IGK) light chain or the lambda light chain (IGL). The best known translocations involving IG light chain loci are the variant Burkitt's translocations t(2;8)(p12;q24) and t(8;22)(q24;q11), present in up to 25% of all Burkitt's lymphomas. Other translocations involve the BCL6 oncogene (t(2;3)(p12;q27) and t(3;22)(q27;q11)) and BCL2 locus (t(2;18)(p12;q21) and t(18;22)(q21;q11)) in follicular lymphoma. These IG light chain translocations may occur in combination in 'double hit' and 'triple hit' lymphomas. The IGK break‑apart FISH probe allows for definitive identification of IGK rearrangement at 2p11.2 in both suspension cultures and FFPE tissues, facilitating clarification of complex karyotypes.
Special Instructions
Not provided.
Limitations
Not provided.
Methodology
Chromosomal / Cytogenetics
Biomarkers
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Paraffin block is the preferred sample type. Sample source and block ID are required on the requisition form and a pathology report must be submitted.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Room temperature (viability decreases during transit; do not freeze) |
Other tests from different labs that may be relevant