FISH, MALT Lymphoma, API2/MALT1, t(11;18)
Use
This fluorescence in situ hybridization (FISH) assay uses a break‑apart probe to detect the API2/MALT1 (BIRC3/MALT1) fusion gene resulting from the t(11;18) translocation. Detection of this translocation aids in the diagnosis of extranodal marginal zone lymphoma of mucosa‑associated lymphoid tissue (MALT lymphoma), which is frequently associated with the BIRC3/MALT1 fusion. The presence of this fusion may have implications for resistance to H. pylori eradication therapy and indicates disease dissemination, particularly in gastric MALT lymphoma.
Special Instructions
Not provided.
Limitations
Because FISH is limited to probing specific chromosomal regions, it does not replace conventional cytogenetic analysis or chromosomal microarray for screening unknown abnormalities.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
API2-MALT1-AS1 fusion
Fusion
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
3 mL aspirate
Minimum Volume
1 mL
Container
sodium heparin (green‑top) tube
Other tests from different labs that may be relevant