Casandra
Casandra Test Code QD94718Version 1 (DRAFT)
Performing Lab
FISH, RUNX1T1/RUNX1 (ETO/AML1), Translocation (8;21)
Also known as: AML, AML1/ETO-FISH, AML-M2 FISH, Acute Myeloid Leukemia
Clinical Use
Order TestUse
This test is performed to detect the RUNX1T1 (ETO;8q22) and RUNX1 (AML1;21q22), translocation t(8;21), by FISH. It is clinically useful for the diagnosis of acute myeloid leukemia (AML) with RUNX1T1/RUNX1 (ETO/AML1) gene fusion.
Special Instructions
Not provided.
Limitations
Not provided.
Test Details
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Unknown CNV
Copy Number RegionFISH
Copy Number Alteration • Categorical (e.g., Positive / Negative / Indeterminate)
Unknown CNV
Copy Number RegionFISH
Copy Number Alteration • Categorical (e.g., Positive / Negative / Indeterminate)
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen Requirements
Specimen
Whole Blood
Volume
5 mL whole blood (preferred) or 3 mL bone marrow
Minimum Volume
1 mL
Container
sodium heparin (green-top) tube; also acceptable royal blue-top or tan-top sodium heparin tube
Collection Instructions
See instructions: clinical history required; do not freeze; maintain viability during transit
Similar Tests
Other tests from different labs that may be relevant
RUNX1T1/RUNX1 (ETO/AML1) t(8;21) FISH
NeoGenomics
Oncology FISH Analysis - AML1/ETO(RUNX1/RUNX1T1): t(8;21) [AML]
Baylor Genetics
AML::ETO; t(8;21)
MPLN
RUNX1::RUNX1T1 (AML1::ETO) t(8;21) Detection, Quantitative
ARUP Laboratories
RUNX1‑RUNX1T1 (AML1‑ETO) Translocation, t(8;21)
NeoGenomics
ETV6::RUNX1; t(12;21)
MPLN
RUNX1::RUNX1T1 Translocation (8;21), Minimal Residual Disease Monitoring, Quantitative, Varies
Mayo Clinic Lab
Oncology FISH Analysis - STAT AML FISH Panel
Baylor Genetics
Oncology FISH Analysis - TEL/AMLI: t(12;21) [ALL]
Baylor Genetics
Acute Myeloid Leukemia (AML) Frontline Panel
MPLN