Gamma-Aminobutyric Acid Receptor, Type A (GABA-AR) Antibody, IgG by CBA-IFA with Reflex to Titer, Serum
Also known as: GABA-A SER
Use
This test aids in the diagnosis of limbic encephalitis and autoimmune epilepsy. It may be used to monitor treatment response in individuals who test positive for antibodies. The presence of GABA-AR antibodies can be associated with refractory seizures, memory loss, behavior changes, abnormal movements, and decreased level of consciousness. GABA-AR encephalitis may have paraneoplastic associations, but the tumor type varies and can include thymoma, small cell lung cancer, rectal cancers, and hematologic malignancies.
Special Instructions
If GABA-AR antibody IgG is positive, then GABA-AR antibody IgG titer will be added, which incurs additional charges. Interpretation of any antineural antibody test requires clinical correlation.
Limitations
A negative test result does not rule out a diagnosis of autoimmune limbic encephalitis or autoimmune epilepsy. Thus, negative results should be interpreted with caution and in conjunction with clinical findings.
New York Approved
Methodology
Cell-based / Cytometry (Immunoassay)
Biomarkers
LOINC Codes
- 101874-6
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.2 mL
Container
ARUP standard transport tube
Collection Instructions
Collect the specimen in a serum separator tube. Separate serum from cells within 2 hours of collection and transfer to the provided transport tube.
Storage Instructions
Refrigerated.
Causes for Rejection
CSF or plasma. Contaminated, grossly hemolyzed, icteric, or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month |
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