Growth Hormone Binding Protein
Use
Reduced or absent GHBP is found in GH insensitivity due to inactivating receptor binding mutations as typified by Laron dwarfism. The most clinically relevant use of GHBP measurements is to confirm suspected Laron dwarf GH insensitivity due to genetic GH receptor defect. Other forms of GH receptor insensitivity, however may have normal or high GHBP levels. The levels of GHBP may be explained by the underlying mechanism for insensitivity, accordingly, inability to dimerize, errors in the trans-membrane structure, or in downstream actions may have high or normal GHBP levels.
Special Instructions
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Limitations
Results of this test are labeled for research purposes only by the assay's manufacturer. The performance characteristics of this assay have not been established by the manufacturer. The result should not be used for treatment or for diagnostic purposes without confirmation of the diagnosis by another medically established diagnostic product or procedure. The performance characteristics were determined by LabCorp.
Methodology
Immunoassay (ELISA)
Biomarkers
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.3 mL
Minimum Volume
0.1 mL
Container
Gel-barrier tube; red-top tube
Collection Instructions
Allow a minimum clotting time of 30 to 60 minutes with serum separation within 2 hours of collection. Send serum in a plastic transport tube.
Storage Instructions
Refrigerate
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
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