HE4, Ovarian Cancer Monitoring
Also known as: Human Epididymis Protein 4
Use
HE4 (Human Epididymis Protein 4) aids in monitoring patients with epithelial ovarian cancer post‑therapy for recurrence or progression; it should not be used as a screening or diagnostic tool for ovarian cancer ([cayugamedlab.testcatalog.org](https://cayugamedlab.testcatalog.org/show/HE4?utm_source=openai)).
Special Instructions
Not provided.
Limitations
Not to be used as a stand‑alone screening test for ovarian cancer; clinical utility limited to epithelial subtype and should be interpreted in context of CA 125 and clinical findings ([hnl.com](https://www.hnl.com/test-directory/human-epididymis-protein-4-he4/ovhe4?utm_source=openai)).
New York Approved
Methodology
Immunoassay (Chemiluminescent Microparticle Immunoassay)
Biomarkers
LOINC Codes
- 55180-4
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
Not provided
Minimum Volume
0.3 mL
Container
Screw‑capped plastic vial
Collection Instructions
Centrifuge, separate serum and send 0.5 mL serum frozen in a screw capped plastic vial ([wardelab.com](https://wardelab.com/test/he4-ovarian-cancer-monitoring/?utm_source=openai)).
Causes for Rejection
Hemolyzed, lipemic or icteric samples, presence of fibrin, red blood cells or other particulate matter ([wardelab.com](https://wardelab.com/test/he4-ovarian-cancer-monitoring/?utm_source=openai))
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Room temperature: 48 hours |
| Refrigerated | Refrigerated: 72 hours |
| Frozen | Frozen: 28 days |
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