Human Epididymis Protein 4

Casandra

Casandra Test Code LC99027Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 081700CPT Code 86305

Human Epididymis Protein 4

Clinical Use

Use

The HE4 assay is utilized as an aid in monitoring recurrence or progressive disease in patients with epithelial ovarian cancer. Serial testing using HE4 assay values should be integrated with other clinical findings for monitoring ovarian cancer. The test shows potential in differentiating ovarian cancer from other types of ovarian conditions.

Special Instructions

Values obtained with different assay methods should not be used interchangeably during serial testing. It is recommended to consistently use only one assay method to monitor each patient's therapy course. The procedure is intended for one-time use only. For serial monitoring, test 481700 is recommended. The test may show interference if the sample is collected from a person consuming high doses of biotin. Patients should be advised to stop biotin usage at least 72 hours prior to sample collection.

Limitations

The HE4 assay is not intended for use as a cancer screening test. HE4 levels may be influenced by age and menstruation onset age, but these effects are minor. In samples with human antimouse antibodies, HE4 values can be falsely altered. The presence of HE4 within the reference range doesn't exclude cancer, and high levels do not definitively indicate malignancy. Certain ovarian cancer types do not express HE4 and the Elecsys HE4 assay is not advised for monitoring mucinous or germ cell ovarian cancer. HE4 may show elevated levels in individuals with non-malignant diseases. Results need to be evaluated along with other clinical laboratory findings.

Test Details