Hepatitis B Virus (HBV) Genotype
Also known as: HBV PreCore Mutations, HBV Subtype
Use
The HBV genotype assay classifies the virus present in the sample into one of nine recognized genotypes (A-I) via sequence analysis of the DNA polymerase gene. Disease progression and response to therapy may be influenced by genotype. In addition, the HBV genotype assay identifies and reports sequence polymorphisms in the basal core promotor (BCP) and coding regions of the HBV precore gene that result in either decreased levels, or complete absence, of HBeAg expression in chronically infected patients.
Special Instructions
Not provided.
Limitations
This assay may not be successful when the HBV viral load is <500 IU/mL. The test has not been cleared or approved by the FDA, but the FDA has determined that such clearance or approval is not necessary.
Methodology
PCR-based (PCR)
Biomarkers
No genes
GeneNo genes
GeneNo genes
Gene
LOINC Codes
- 32366-7 - HBV Gentyp SerPl NAA+probe
- 54210-0 - HBV BCP Mut Ser NAA+probe
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1.2 mL
Minimum Volume
600 μL
Container
Gel-barrier tube, yellow-top (ACD) tube, lavender-top (EDTA) tube or PPT
Collection Instructions
Centrifuge sample within six hours of collection, transfer plasma/serum to a polypropylene screw-cap tube and freeze.
Storage Instructions
Freeze.
Causes for Rejection
Quantity not sufficient for analysis; heparin/SPS plasma (wrong anticoagulant); gross hemolysis; specimen not frozen
Other tests from different labs that may be relevant