Hepatitis C Virus High-Resolution Genotype by Sequencing
Also known as: HCV CORE
Use
This test is used for the determination of hepatitis C virus genotypes with high-resolution sequencing to aid in prognosis and therapy selection, differentiate between subtypes (such as 1a vs. 1b), and assist in the management of chronic hepatitis C infections. The genotyping is critical for appropriate treatment decisions, especially with varying responses to therapy among different genotypes and subtypes.
Special Instructions
Order this test before initiating HCV therapy to assist in prognosis and therapy selection, specifically when higher subtype resolution (e.g., non 6a/b vs. type 1; 1a vs. 1b) is needed. It should not be ordered prior to molecular confirmation of a positive HCV screen. Submission of the most recent viral load and test date is requested if available.
Limitations
The test may be unsuccessful if the HCV RNA viral load is below log 4.2 or 16,000 IU/mL. Other conditions, like PCR inhibitors or viral genetic variations, may also cause RT-PCR failures, resulting in indeterminate genotyping results. The test's performance characteristics were determined by ARUP Laboratories and have not been cleared or approved by the U.S. FDA. The test is conducted in a CLIA-certified laboratory for clinical purposes.
New York Approved
Methodology
PCR-based (Sequencing)
Biomarkers
LOINC Codes
- 32286-7
Result Turnaround Time
5-8 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
2 mL
Minimum Volume
0.5 mL
Container
EDTA or SST tube
Collection Instructions
Separate from cells ASAP or within 24 hours of collection and transfer to an ARUP transport tube.
Causes for Rejection
Heparinized specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | 72 hours |
| Frozen | 4 months |
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