Human Immunodeficiency Virus 1 (HIV-1) PhenoSense GT® Plus Integrase (Monogram® Phenotype + Genotype)
Also known as: HIV Resistance, PhenoSense GT® Plus Integrase
Use
Determines viral phenotype and genotype resistance to four classes of commonly prescribed antiretroviral drugs: nucleoside reverse transcriptase inhibitors (NRTI), nonnucleoside reverse transcriptase inhibitors (NNRTI), protease inhibitors (PI), and integrase inhibitors (INI).
Special Instructions
A separate frozen specimen is required for each frozen test ordered. Collect plasma in three lavender-top (EDTA) tubes or PPT™ tubes, centrifuge within six hours, transfer to screw-capped tubes, and freeze. Do not use green-top (heparin) tubes. Ship specimens frozen and avoid delays by submitting separate samples for each test.
Limitations
The procedure is intended for patients with documented HIV-1 infection and viral loads ≥500 copies/mL. Insufficient virus quantity may lead to alternative testing, with additional billing applied. Nonfrozen specimens, as well as those that experience repeated freeze/thaw cycles, will be rejected. PPT™ tubes must be centrifuged, and heparinized plasma will be discarded.
Methodology
PCR-based (PCR)
Biomarkers
LOINC Codes
- 83326-9
- 51969-4
- 83326-9
- 49665-3
- 80689-3
- 77202-0
Result Turnaround Time
19-23 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
5 mL
Minimum Volume
Not provided
Container
Lavender-top (EDTA) tubes or PPT™ tubes
Collection Instructions
Centrifuge specimen within six hours of collection. Transfer plasma to one or more polypropylene screw-capped tube(s) and freeze. Ship specimen frozen.
Storage Instructions
Freeze.
Causes for Rejection
PPT™ not centrifuged; quantity not sufficient for analysis; heparinized plasma; nonfrozen specimens; specimens exposed to repeated freeze/thaw cycles; specimen received in 'pop-top' or 'snap-cap' tube
Other tests from different labs that may be relevant