Human Immunodeficiency Virus 1 (HIV-1) PhenoSense® (Monogram® Phenotype)
Also known as: HIV-1 Resistance Testing, Phenotyping
Use
Determines viral phenotype resistance to three classes of commonly prescribed antiretroviral drugs: nucleoside reverse transcriptase inhibitors (NRTI), non-nucleoside reverse transcriptase inhibitors (NNRTI), and protease inhibitors (PI). Viral replication capacity is also included.
Special Instructions
Not provided.
Limitations
This test is intended for patients with documented HIV-1 infection. It should not be used as the sole criterion for patient management. Results should be interpreted in the context of clinical presentation and drug treatment history, as various factors can influence phenotypic expression. The procedure is validated only for HIV-1 viral loads above 500 copies/mL.
Methodology
Culture-based
Biomarkers
Unknown protein
Protein
LOINC Codes
- 49665-3 - HIV Susc Pnl Islt Phenotyp
- 45182-3 - HIV Phenotyp Islt
- 49665-3 - HIV Susc Pnl Islt Phenotyp
- 48767-8 - Annotation comment Imp
Result Turnaround Time
16-22 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
3 mL
Minimum Volume
Not provided
Container
Lavender-top (EDTA) or plasma preparation tube (PPT™)
Collection Instructions
Collect specimen in two lavender-top (EDTA) tubes or two PPT™ tubes. Do not use green-top (heparin) tubes. Centrifuge specimen within six hours of collection. Transfer plasma to one or more polypropylene screw-capped tube(s), and freeze. Ship specimen frozen.
Storage Instructions
Freeze
Causes for Rejection
PPT™ not centrifuged; quantity not sufficient for analysis; heparinized plasma; nonfrozen specimen; specimen exposed to repeated freeze/thaw cycles; specimen received in 'pop-top' or 'snap-cap' tube
Other tests from different labs that may be relevant