Human Papillomavirus (HPV), Biopsy in situ Hybridization Low- and High-risk Subtypes
Also known as: HPV by ISH
Use
Determine HPV type; confirm HPV infection; resolve cases with equivocal histopathology
Special Instructions
Not provided.
Limitations
The assay can identify only six specific HPV types and is unable to detect other HPV types beyond 6, 11, 16, 18, 31, and 33. It is important to note that while more than 20 distinct HPV types have been associated with the anogenital mucosa, this test does not provide a complete profile of all potential HPV types affecting the mucosal tissue. Additionally, the test has not received clearance or approval from the FDA, which may limit its applicability to certain diagnostic settings. The results should be considered in context with clinical findings and other diagnostic procedures.
Methodology
Chromosomal / Cytogenetics (ISH)
Biomarkers
LOINC Codes
- 18480-4 - HPV6+11 DNA Tiss Ql Probe
- 18478-8 - HPV16+18 DNA Tiss Ql Probe
- 81439-2 - HPV31+33 DNA Tiss Ql Probe
- 77202-0 - Laboratory comment Report
- 72486-4 - Lab director name Provider
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
One formalin-fixed, paraffin embedded (FFPE) tissue block or eight unstained slides
Minimum Volume
Five unstained tissue slides
Container
Paraffin block transport pouch or slide container
Collection Instructions
Tissue biopsy should be fixed in 10% neutral buffered formalin for no more than 72 hours. Embed in paraffin.
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Insufficient tissue; inappropriate tissue source; incorrect specimen type
Other tests from different labs that may be relevant