Hymenoptera Venom Allergy (HVA) With Components Profile

Casandra

Casandra Test Code LC07344Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 606220CPT Codes 83520, 86003, 86008

Hymenoptera Venom Allergy (HVA) With Components Profile

Also known as: Honey Bee, Paper Wasp, Stinging Insects, Venom, Yellow Jacket

Clinical Use

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Use

Support the diagnosis of hymenoptera venom allergy (HVA) by detection of sIgE antibodies to whole venom extracts and individual allergenic venom proteins. Identifying sIgE responses to specific molecular targets with component resolved diagnostics (CRD) helps fine-tune the diagnosis by distinguishing species-specific, co-reactive, or cross-reactive sensitizations. An accurate diagnosis, in turn, facilitates treatment, including prescription of venom immunotherapy.1

Special Instructions

Reflex testing may incur additional CPT codes and charges. If any of the criteria for reflex testing are met, Cross-reactive Carbohydrate Determinant (CCD) IgE is performed. These include criteria related to Honey Bee Venom, Yellow Jacket Venom, and Paper Wasp Venom IgE levels and specific component negativity.

Limitations

The prevalence of asymptomatic sensitization to hymenoptera venom poses challenges in accurately diagnosing Hymenoptera venom allergy. There is no direct correlation between venom sIgE levels and the severity of sting reactions. Patients may experience severe anaphylaxis despite low or absent specific IgE levels. Negative allergy test outcomes can occur due to several factors, such as testing during the refractory period, loss of sensitization, and systemic mastocytosis, among others.

Test Details