Immunofixation with Free Light Chains, Quantitative, Urine
Also known as: U IFE FLC
Use
The Immunofixation with Free Light Chains, Quantitative, Urine test is useful for the monitoring of patients with urinary monoclonal proteins (Bence Jones protein). This test can help identify the presence of free light chains in urine which are important for diagnosing and managing plasma cell dyscrasias. Free light chains are an indicator of disease progression or therapeutic response in patients where urine electrophoresis cannot reliably quantify Bence Jones Protein.
Special Instructions
Not provided.
Limitations
Results of urine kappa and lambda free light chain quantitative analysis may be misleading in the presence of high levels of urinary polyclonal free light chains and absent Bence Jones protein by immunofixation. It is recommended to correlate these findings with urine immunofixation to avoid misinterpretation. Additionally, undetected antigen excess is a rare event that can occur and should be considered when interpreting results. This test may not agree with total protein levels determined by chemical methods, which can underestimate urinary light chains.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Immunoturbidimetry)
Biomarkers
Free Urinary Kappa Light Chains
ProteinFree Urinary Lambda Light Chain
Protein
LOINC Codes
- 2889-4 - Prot 24h Ur-mRate
- 38176-4 - Kappa LC Free Ur-mCnc
- 38177-2 - Kappa LC Free 24h Ur-mRate
- 38178-0 - Lambda LC Free Ur-mCnc
- 38169-9 - Lambda LC Free 24h Ur-mRate
- 49277-7 - Interpretation 24h Ur IFE-Imp
- 19153-6 - Specimen vol ?Tm Ur
- 30211-7 - Specimen collect Time Spec
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
Two 4 mL aliquots
Minimum Volume
4 mL
Container
ARUP Standard Transport Tubes
Collection Instructions
For a 24-hour collection, collect all urine and refrigerate during the collection period. Alternatively, random urine specimens and urine supernate are acceptable.
Storage Instructions
Refrigerate during collection. Once collected, transport at refrigerated temperature.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | 3 weeks |
| Frozen | 6 months |
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