Inositol 1,4,5-Trisphosphate Receptor Type 1 (ITPR1) Antibody, IgG by CBA-IFA With Reflex to Titer, CSF
Also known as: ITPR1 CSF
Use
Aids in the diagnosis of autoimmune cerebellar ataxia, encephalitis, neuropathy, and myelopathy. The presence of ITPR1 antibodies may be associated with cerebellar ataxia, encephalitis with seizures, peripheral neuropathy, and myelopathy. ITPR1 antibody disease may be paraneoplastic, but tumor type is variable (e.g., breast, lung, and renal cancers). It can also be used to monitor treatment response in antibody-positive individuals.
Special Instructions
If ITPR1 antibody IgG is positive, then ITPR1 antibody IgG titer will be added. Additional charges apply.
Limitations
A negative test result does not rule out a diagnosis of autoimmune cerebellar ataxia or related autoimmune neurologic disorders. Interpretation of any antineural antibody test requires clinical correlation. The test has been developed and its performance characteristics determined by ARUP Laboratories, but it has not been cleared or approved by the U.S. FDA.
New York Approved
Methodology
Immunoassay (Indirect Fluorescent Antibody)
Biomarkers
LOINC Codes
- 96468-4
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
0.5 mL
Minimum Volume
0.15 mL
Container
ARUP standard transport tube
Collection Instructions
Separate CSF and transfer 0.5 mL to an ARUP standard transport tube.
Causes for Rejection
Grossly hemolyzed or contaminated specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month (Three freeze/thaw cycles are acceptable) |
Other tests from different labs that may be relevant