Insulin-like Growth Factor-binding Protein 1 (IGFBP-1) (Endocrine Sciences)

Casandra

Casandra Test Code LC86582Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 140822CPT Code 83520

Insulin-like Growth Factor-binding Protein 1 (IGFBP-1) (Endocrine Sciences)

Also known as: IGF-binding Protein 1, IGFBP-1

Clinical Use

Order Test

Use

Identify women who are at high risk for developing preëclampsia

Special Instructions

Serum levels of IGFBP-1 exhibit considerable diurnal variation, with levels highest early in the morning and lowest in the evening. Serum IGFBP-1 levels are controlled by insulin, with postprandial insulin increasing significantly, leading to a four- to fivefold decrease in IGFBP-1 levels compared to fasting levels. It is essential to freeze serum samples immediately after collection and maintain them frozen until testing to ensure validity of the test results.

Limitations

Patients with growth hormone deficiency tend to have elevated IGFBP-1 levels, while those with type 2 diabetes, acromegaly, Cushing disease, and polycystic ovary syndrome tend to have low levels. The diurnal variation and rapid decrease in IGFBP-1 postprandial could impact the test's readings. Various physiological conditions such as fasting state and use of certain medications might affect the test results.

Test Details

Methodology

Immunoassay (ECLIA)

Biomarkers

IGFBP-1

Protein

Insulin-like Growth Factor-binding Protein 1 • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Result Codes

12722-5

Result Turnaround Time

6-12 days

Specimen

Serum

Volume

0.5 mL

Minimum Volume

0.1 mL

Container

Red-top tube or gel-barrier tube

Collection Instructions

Transfer the serum into a Labcorp PP transpak frozen purple tube with screw cap (Labcorp No. 49482). Freeze immediately and maintain frozen until tested. Submit separate frozen specimens for each test if multiple tests are ordered.