Islet Antigen-2 (IA-2) Autoantibody, Serum
Also known as: IA-2 AB
Use
This assay is intended for the quantitative determination of autoantibodies to Islet Antigen-2 (IA-2) in human serum. It is used to establish an autoimmune etiology in patients with previously diagnosed type 1 diabetes mellitus (DM). A value greater than or equal to 7.5 Units/mL is considered positive for IA-2 autoantibodies. The test is most useful for identifying autoimmune diabetes mellitus and should be considered in cases where autoimmune diabetes is suspected, especially when differentiating from other types of diabetes mellitus.
Special Instructions
For testing autoimmune diabetes mellitus, it is advised to perform at least two antibody tests. In most cases, this should include the glutamic acid decarboxylase antibody test in combination with another antibody test, such as IA-2. The test should not be used to differentiate type 1 DM from type 2 DM in most cases. Patient preparation involves collecting a serum specimen.
Limitations
The test is not designed to differentiate type 1 DM from type 2 DM in most instances. It should not be relied upon in isolation and should be interpreted within the context of clinical symptoms and other diagnostic tests. Unacceptable specimens include plasma, specimens in frozen SST, and grossly hemolyzed, icteric, or lipemic specimens. Results may be affected by improper specimen handling or preparation methods.
FDA ApprovedNew York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 56718-0
Result Turnaround Time
2-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.35 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Collect using a plain red or serum separator tube (SST).
Storage Instructions
Refrigerate specimens for transport. Avoid plasma and frozen SSTs.
Causes for Rejection
Plasma, frozen serum separator tubes, grossly hemolyzed, icteric, or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 1 week |
| Frozen | 2 months |
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