Lead, Random Urine

Casandra

Casandra Test Code AR24099Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 2011482CPT Code 83655

Also known as: U LEADRAND

Clinical Use

Order Test

Use

This test is used to assess chronic lead exposure and monitor chelation therapy. Lead levels in random urine samples can indicate the degree of exposure to lead, especially in cases where blood lead levels are challenging to assess. Urinary excretion of lead increases following chelation therapy, which can be used as a therapeutic monitoring strategy.

Special Instructions

Dietary supplements, vitamins, minerals, and nonessential medications may introduce substances that interfere with the test. High concentrations of iodine may affect test results, hence collection should be avoided for at least 72 hours after exposure to iodinated or gadolinium-based contrast media. Patients with impaired kidney function should avoid urine collection for 14 days post-contrast exposure.

Limitations

Results may be affected by contamination during collection, specifically if non-trace element-free containers are used. Elevated results suspected to be due to contamination should be confirmed with a second specimen in certified trace element-free containers. Urinary lead excretion greater than 125 micrograms per 24 hours is generally associated with lead toxicity, but results should be interpreted along with clinical presentation and other tests for lead exposure, such as blood lead levels.

Test Details

New York Approved

Methodology

Mass Spectrometry

Biomarkers

Creatinine, Urine - per volume

Analyte

Creatinine, Urine - per volume • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

Lead, Urine - per volume

Analyte

Lead, Urine - per volume • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

Lead, Urine - ratio to CRT

Analyte

Lead, Urine - ratio to CRT • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Order Codes

0025062
0025065

Result Codes

35674-1
30931-0
13466-8

Result Turnaround Time

1-5 days

Specimen

Urine

Volume

8 mL

Minimum Volume

1 mL

Container

ARUP Trace Element-Free Transport Tubes

Collection Instructions

Collect random urine. Avoid collection within 72 hours after administration of iodinated or gadolinium-based contrast media. Transfer 8 mL aliquot from a well-mixed collection to appropriate transport tubes.