Liver-Kidney Microsome - 1 Antibody, IgG
Also known as: LKM1 IGG
Use
The Liver-Kidney Microsome - 1 Antibody, IgG test is used in the differential evaluation of autoimmune liver disease of unknown etiology, especially autoimmune hepatitis (AIH) of childhood onset. A positive result indicates the presence of IgG antibodies to recombinant human P450 2D6 and suggests the possibility of autoimmune hepatitis, type 2. However, a negative LKM-1 result does not rule out the presence of autoimmune hepatitis, type 2.
Special Instructions
Use this test in combination with Liver Cytosolic Antigen Type 1 (LC-1) Antibody, IgG (2010711) when evaluating for AIH-2. Ensure serum is separated from cells ASAP or within 2 hours of collection and transferred to an ARUP Standard Transport Tube.
Limitations
The test may not detect all individuals with autoimmune hepatitis, type 2, as a negative result does not exclude the disease. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens are unacceptable and can affect the test result.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 47318-1
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection. Transfer to an ARUP Standard Transport Tube.
Storage Instructions
Refrigerated.
Causes for Rejection
Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient: 48 hours |
| Refrigerated | Refrigerated: 2 weeks |
| Frozen | Frozen: 1 year (avoid repeated freeze/thaw cycles) |
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