LRP4 Autoantibody Test
Use
Detects anti‑LRP4 (low density lipoprotein receptor‑related protein 4) in the sera of patients with Myasthenia Gravis (MG). LRP4 activates MuSK kinase activity and promotes acetylcholine receptor clustering and stabilization at the neuromuscular junction; anti‑LRP4 antibodies are found in approx. 9.2% (range 2%–50%) of MG patients who are negative for both anti‑AChR and anti‑MuSK. Quest offers this as a standalone orderable test. ([intellitestmanager.questdiagnostics.com](https://intellitestmanager.questdiagnostics.com/home/output/206877?utm_source=openai))
Special Instructions
Not provided.
Limitations
Not provided.
Methodology
Immunoassay (Other)
Biomarkers
LRP4 antibody
Protein
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
0.5 mL
Container
serum tube
Collection Instructions
Please label each specimen tube with two forms of patient identification; these must match the requisition form.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
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