Lupus Anticoagulant Reflex Panel
Also known as: LUPUS RFLX
Use
The Lupus Anticoagulant Reflex Panel is used as an aid in the evaluation of unexplained prolonged partial thromboplastin time (PTT) or for patients with a significant probability of having antiphospholipid syndrome (APS). It helps identify the presence of lupus anticoagulant, which is associated with an increased risk of thrombosis. For evaluating APS, it is recommended to use this panel in conjunction with tests for Cardiolipin and Beta-2 Glycoprotein 1 antibodies.
Special Instructions
If PTT-LA Ratio and dRVVT Screen Ratio are normal, no further testing is conducted. If either ratio is elevated, additional tests like Anti-Xa Qualitative Interpretation and Thrombin Time are added. Hepzyme or DOAC-Stop treatments may be applied based on further test results. Additional tests such as Neutralized Ratio and Hexagonal Phospholipid Confirmation might be included, and extra charges apply.
Limitations
Testing is optimally performed in the absence of anticoagulant medications to avoid erroneous results. Acute inflammation or high concentrations of anticoagulant medications may lead to false positives. Lupus anticoagulant testing should be conducted when patients are not acutely ill to ensure accurate results. Heterogeneous lupus anticoagulant antibodies and fluctuating antibody titers can affect test sensitivity.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 5902-2
- 48022-8
- 15359-3
- 3243-3
- 3269-8
- 97641-5
- 75512-4
- 50410-0
- 75883-9
- 75882-1
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
3 mL
Minimum Volume
2 mL
Container
Light blue (sodium citrate)
Collection Instructions
Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.
Storage Instructions
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Causes for Rejection
Serum, EDTA plasma, clotted or hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 hours |
| Refrigerated | Unacceptable |
| Frozen | 3 months |
Other tests from different labs that may be relevant