Oncology FISH Analysis - Deletion 7 [MDS]
Use
Oncology FISH Analysis – Deletion 7 [MDS] is a specialized FISH test aimed at detecting a prevalent chromosome deletion associated with myelodysplastic syndrome (MDS), a group of blood cancers including acute myeloid leukemia (AML) which primarily affect adults. The analysis is crucial for patients exhibiting clinical or suspected signs of MDS and serves to identify prognostic anomalies in diagnosed individuals. It's vital to remember that the outcomes of this test should always be evaluated alongside appropriate clinical and pathological data, rather than being solely used for a definitive diagnosis of MDS. The test is especially important in instances where previous cytogenetic tests have yielded inconclusive results, and it plays a pivotal role in monitoring treatment response, helping clinicians make informed decisions regarding patient care.
Special Instructions
When submitting samples for the test, it is critical to draw the appropriate type of specimen, which includes bone marrow in a Sodium Heparin tube or leukemic blood. Ensure that samples are shipped at room temperature in an insulated container to maintain specimen integrity. Results from this test can aid in prognostic identification for diagnosed patients, especially when previous cytogenetic tests have failed or for tracking responses to therapy.
Limitations
This FISH assay is specifically focused on the detection of deletion of chromosome 7. Consequently, it is unable to identify any abnormalities pertaining to other chromosomes or genes, limiting its diagnostic applicability. It is essential to acknowledge that while this test can highlight critical chromosomal deletions, it cannot serve as a standalone diagnostic tool for myelodysplastic syndrome without correlation to other clinical findings and tests.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow (Fresh)
Volume
3-5 cc (Adults/Children) or 2 cc (Infants<2 years)
Minimum Volume
3-5 cc
Container
Sodium Heparin Tube (Green-Top)
Collection Instructions
Draw bone marrow in a Sodium Heparin (green-top) tube(s).
Storage Instructions
Ship at ambient temperature (18-25°C/64-77°F).
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hrs |
Other tests from different labs that may be relevant