Procollagen Type I Intact N-Terminal Propeptide

Casandra

Casandra Test Code AR41339Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0070236CPT Code 83519

Procollagen Type I Intact N-Terminal Propeptide

Also known as: PINP

Clinical Use

Order Test

Use

The Procollagen Type I Intact N-Terminal Propeptide (PINP) test is used to assess bone turnover, particularly in the context of osteoporosis. It measures the levels of PINP, a marker which reflects the rate of bone formation. Elevated levels may indicate higher bone turnover, while lower levels can be seen in conditions with suppressed bone formation. PINP testing is useful as part of a comprehensive assessment of skeletal health and helps clinicians in evaluating and monitoring treatment efficacy in osteoporosis management.

Special Instructions

Ensure that all specimens are collected at the same time of day due to the diurnal variation of PINP, with values typically higher at night. Use a serum separator tube or plain red tube for collection. The ordering clinician should be aware of the specific specimen handling requirements to maintain sample stability and integrity.

Limitations

The test has limitations in differentiating between increased bone turnover due to physiological conditions such as growth, and pathological conditions like osteoporosis or metastatic bone cancer. Hemolyzed or lipemic specimens are unsuitable as they can interfere with the assay results. Plasma specimens are also unacceptable due to potential interference in the assay. Since the test is based on radioimmunoassay technology, cross-reactivity with other molecules present in the serum may affect the result accuracy.

Test Details

FDA Approved

New York Approved

Methodology

Immunoassay (RIA)

Biomarkers

LOINC Codes

Order Codes

47255-5

Result Turnaround Time

1-8 days

Specimen

Serum

Volume

0.5 mL

Minimum Volume

0.2 mL

Container

ARUP Standard Transport Tube

Collection Instructions

Collect all specimens at the same time of day; there is a diurnal variation of PINP and values are higher at night. Allow serum tube to sit for 15-20 minutes at room temperature for proper clot formation. Centrifuge and separate serum from cells ASAP or within 2 hours of collection.