Intact N-Terminal Propeptide of Type 1 Procollagen
Also known as: PINP
Use
This test is used for measurement of Intact N-Terminal Propeptide of Type 1 Procollagen (PINP) levels in serum.
Special Instructions
Patients should be asked about biotin supplementation as it can interfere with the test. It is advised to stop biotin consumption at least 72 hours before sample collection. The test may exhibit interference from supplements with high doses of biotin, also known as vitamin B7, vitamin B8, vitamin H, or coenzyme R.
Limitations
The test was developed by Labcorp and has not been cleared or approved by the FDA. It may exhibit limited specificity as it reflects bone turnover in general, and severe liver disease may affect its clearance from circulation, leading to elevated serum PINP levels. Heterophilic antibodies may cause erroneous results. Samples should be collected at the same time of day for subsequent evaluations due to diurnal variation.
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 47255-5
- 47255-5
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.4 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from cells within 45 minutes of collection. If a red-top tube is used, transfer separated serum to a plastic transport tube.
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Nonserum sample received
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
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