Scleroderma Antibody (Scl‑70)
Use
Antibodies to Scl‑70 (topoisomerase I) are a specific marker for systemic sclerosis (scleroderma), particularly associated with the diffuse form, and are found in approximately 20%–60% of patients, most often around 40% of Progressive Systemic Sclerosis (PSS) cases. Their presence is considered diagnostic in the appropriate clinical context.
Special Instructions
Not provided.
Limitations
Gross hemolysis, lipemia, and icterus may interfere with assay performance and lead to rejection of the specimen.
Methodology
Immunoassay
Biomarkers
Scl‑70 (topoisomerase I) antibody
Protein
Result Turnaround Time
3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 yellow‑top SST tube (minimum: 0.5 mL serum)
Minimum Volume
0.5 mL
Container
Yellow‑top SST tube
Collection Instructions
Centrifuge SST 30 minutes after draw; refrigerate after collection
Storage Instructions
Refrigerate after collection
Causes for Rejection
Gross hemolysis; lipemia; icterus
Other tests from different labs that may be relevant