Smith/RNP (ENA) Antibody, IgG
Also known as: RNP
Use
Smith/RNP antibodies are frequently seen in patients with mixed connective tissue disease (MCTD) and are also associated with other systemic autoimmune rheumatic diseases (SARDs), such as systemic lupus erythematosus (SLE), systemic sclerosis, and myositis. Antibodies targeting the Smith/RNP antigenic complex also recognize Smith antigens, therefore, the Smith antibody response must be considered when interpreting these results.
Special Instructions
An affinity purified RNP/Sm antigen complex is used in this assay.
Limitations
Plasma or other body fluids, contaminated, hemolyzed, or severely lipemic specimens are unacceptable conditions. Stability after separation from cells is ambient for 48 hours, refrigerated up to 2 weeks, and frozen for 1 month with avoidance of repeated freeze/thaw cycles.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 33983-8
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection.
Storage Instructions
Refrigerated.
Causes for Rejection
Plasma or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month (avoid repeated freeze/thaw cycles) |
Other tests from different labs that may be relevant