Syphilis: Treponemal Antibodies, Chemiluminescence Immunoassay

Casandra

Casandra Test Code LC58853Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 082370CPT Code 86780

Syphilis: Treponemal Antibodies, Chemiluminescence Immunoassay

Also known as: Syphilis, Treponemal

Clinical Use

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Use

This test detects antibodies to Treponema pallidum and can be used in conjunction with a nontreponemal assay to aid in the diagnosis of syphilis infection. This test is not recommended as a stand-alone test for general screening purposes for syphilis, nor should it be used to evaluate response to therapy. To screen for and diagnose syphilis infection, a reflex cascade that includes both RPR and a treponemal-specific assay should be utilized per current guidelines.

Special Instructions

The test is not recommended as a stand-alone for general screening and should not be used to evaluate response to therapy. It is recommended to use this test in conjunction with a nontreponemal assay for syphilis diagnosis.

Limitations

Treponemal antibodies typically persist for life despite treatment; thus, this assay cannot be used to monitor response to treatment or to assess treatment outcomes. False positive treponemal antibody results have been observed in individuals with nonsyphilis treponemal infections, such as bejel, pinta, and yaws.

Test Details