Varicella-Zoster Virus Antibodies, IgG and IgM

Casandra

Casandra Test Code AR74987Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0050162CPT Code 86787

Varicella-Zoster Virus Antibodies, IgG and IgM

Also known as: VZV PAN

Clinical Use

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Use

This test aids in diagnosing acute Varicella-Zoster infections and detecting past exposure or vaccination. It measures the presence of IgG and IgM antibodies to determine if an individual has a current infection, has been exposed in the past, or has been vaccinated against the virus. Varicella-Zoster Virus, also known as Herpes Zoster or VZV, can cause chickenpox upon primary infection and shingles upon reactivation. Identification of the IgM antibody indicates a current or recent infection, while the presence of the IgG antibody could indicate either a past infection or vaccination.

Special Instructions

Parallel testing is preferred for accurate diagnosis, and convalescent specimens should be received within 30 days from the receipt of acute specimens. Clearly mark specimens as "acute" or "convalescent" when submitting for testing. Ensure serum separation from cells as soon as possible or within two hours of collection for optimal results.

Limitations

The semi-quantitative nature of this test means it may not definitively distinguish between past and acute infections, especially in cases where low levels of IgM antibodies persist for more than 12 months post-infection or immunization. Repeat testing is suggested for equivocal IgM levels between 0.91 and 1.09 ISR. The test's sensitivity and specificity should also be considered when interpreting results.

Test Details

FDA Approved