Voltage-gated Calcium Channel Antibody (VGCCA)
Also known as: Lambert-Eaton Myasthenic Syndrome Antibody, LEMS Autoantibody, P/Q Type VGCC, VGCC Antibody, VGCCA
Use
Measurement of P/Q-type voltage-gated calcium channel (VGCC) antibodies as an aid in the diagnosis of Lambert-Eaton myasthenic syndrome (LEMS)
Special Instructions
Patient should have no radioactive isotopes administered 24 hours prior to venipuncture. Serum should be separated from cells within one hour and transferred to a plastic transport tube.
Limitations
The test may not effectively differentiate between all types of VGCC antibodies beyond P/Q-type. The presence of acetylcholine receptor antibodies can confound results. Results should be interpreted in conjunction with clinical presentation and other diagnostic findings. False positives may occur in individuals with certain neurological or neoplastic disorders.
Methodology
Immunoassay (RIA)
Biomarkers
LOINC Codes
- 31024-3
- 31024-3
Result Turnaround Time
3-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.4 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Serum should be separated from cells within one hour and transferred to a plastic transport tube.
Patient Preparation
Patient should have no radioactive isotopes administered 24 hours prior to venipuncture.
Storage Instructions
Room temperature
Causes for Rejection
Nonserum specimen; gross hemolysis; gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
Other tests from different labs that may be relevant