11-Deoxycorticosterone Quantitative by HPLC-MS/MS, Serum or Plasma
Also known as: DCRN
Use
This test measures the level of 11-Deoxycorticosterone in serum or plasma using quantitative high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). It is useful for assessing the secretion of adrenal steroids, evaluating adrenal gland disorders, and monitoring conditions involving abnormal steroid metabolism. The test provides important information for diagnosing and managing adrenal diseases such as congenital adrenal hyperplasia and other disorders affecting steroid synthesis.
Special Instructions
The test is clinically performed on specific days, being offered on Monday, Wednesday, and Friday, making planning for sample collection important. Clinicians should ensure that the specimen is collected in the appropriate tubes and adhere to specified sample handling and preparation instructions.
Limitations
The test may not be suitable for samples that are grossly hemolyzed, as this condition might affect the accuracy of the results. Additionally, the test may not have been cleared by the FDA, indicating that it should be performed and results interpreted within the context of a CLIA certified laboratory.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 1656-8
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
ARUP standard transport tube
Collection Instructions
Collect serum in a serum separator tube. Also acceptable are plain red, pink (K2EDTA), plasma separator tube, green (sodium heparin), or green (lithium heparin).
Storage Instructions
Refrigerated. Also acceptable: Frozen.
Causes for Rejection
Grossly hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | 1 week |
| Frozen | 6 months |