Antithrombin, Enzymatic (Activity)
Also known as: AT3
Use
The Antithrombin, Enzymatic (Activity) test is recommended to detect antithrombin deficiency, which can be a risk factor for thrombosis if inherited. It helps in diagnosing antithrombin deficiency by excluding other acquired conditions that can cause decreased antithrombin levels, such as liver disease, acute thrombosis, or heparin therapy.
Special Instructions
Ensure separated specimens are submitted when multiple tests are ordered to avoid cross-contamination. Specimens must be critically frozen to maintain sample integrity.
Limitations
Antithrombin activity might be artificially overestimated in the presence of direct thrombin inhibitors. It is important to exclude anticoagulant medications as potential causes of altered antithrombin levels before diagnosing inherited deficiency. The test may yield false results if specimen collection guidelines are not strictly followed, especially regarding freezing and transportation conditions.
FDA Approved
Methodology
Other
Biomarkers
LOINC Codes
- 27811-9
- 27811-9
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1.5 mL
Minimum Volume
1 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Collect in a Lt. blue (sodium citrate) tube. Transfer 1.5 mL of platelet-poor plasma to the transport tube.
Storage Instructions
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Causes for Rejection
Serum, EDTA plasma, clotted or hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 hours |
| Refrigerated | Unacceptable |
| Frozen | 1 month |