Autoimmune Stiff-Person Disorders, CSF
Also known as: AISPSC
Use
This test is used to evaluate symptoms such as stiffness, spasms, hyperekplexia, limb rigidity, myoclonus, or limb dystonia, which may or may not be associated with encephalopathy. Testing both serum and cerebrospinal fluid (CSF) is recommended to enhance diagnostic accuracy. The test can help diagnose conditions such as Stiff-Person Syndrome and other immune-mediated movement disorders.
Special Instructions
Not provided.
Limitations
The test is not FDA cleared or approved. A negative result does not rule out autoimmune neurologic disease, as antibody presence may vary. Results should be interpreted considering the patient's clinical history and other laboratory findings. The methodology might not detect all variants or manifestations of the disorder.
New York Approved
Methodology
Cell-based / Cytometry
Biomarkers
LOINC Codes
- 42501-7 - GAD65 Ab CSF-aCnc
- 57750-2 - Amphiphysin Ab CSF Ql IB
- 94283-9 - DPPX IgG CSF Ql CBA IFA
- 42501-7 - GAD65 Ab CSF-aCnc
- 57750-2 - Amphiphysin Ab CSF Ql IB
- 94283-9 - DPPX IgG CSF Ql CBA IFA
Result Turnaround Time
3-10 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
3 mL
Minimum Volume
0.5 mL/aliquot
Container
ARUP standard transport tubes
Collection Instructions
Transfer three 1 mL CSF aliquots to ARUP standard transport tubes.
Storage Instructions
Keep frozen, avoid repeated freeze/thaw cycles.
Causes for Rejection
Fluid other than CSF. Grossly hemolyzed specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 1 week |
| Frozen | 30 days |
Other tests from different labs that may be relevant