Stiff-Person Disorders Profile, Spinal Fluid
Also known as: Stiff-Person Spectrum Disorders, Stiff-Person Syndrome
Use
This test is recommended for the assessment of stiff-person disorders, whether they manifest in classical or focal forms. This includes symptoms like stiffness, spasms, hyperekplexia, limb rigidity, myoclonus or limb dystonia, regardless of the presence or absence of encephalopathy.
Special Instructions
Not provided.
Limitations
The absence of positive test results does not exclude the possibility of stiff-person spectrum disorders. Low titer results of GAD65 antibody should be interpreted with caution. GAD65 is associated with other autoimmune disorders that may lead to neurological symptoms, such as type 1 diabetes and hypothyroidism. The test has not been cleared or approved by the FDA.
Methodology
Immunoassay (Immunofluorescence)
Biomarkers
Amphiphysin
ProteinDipeptidyl-peptidase-like protein-6 (DPPX)
ProteinGlutamic acid decarboxylase 65 (GAD65)
Protein
LOINC Codes
- 57750-2 - Amphiphysin Ab CSF Ql IB
- 101242-6 - DPPX Ab CSF Ql IF
- 101232-7 - GAD65 Ab CSF Ql IB
- 77202-0 - Laboratory comment Report
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
2 mL
Minimum Volume
1 mL
Container
Single sterile tube of CSF
Collection Instructions
Collect entire sample into a single sterile tube.
Storage Instructions
Room temperature
Causes for Rejection
Gross hemolysis; grossly lipemic; gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
Other tests from different labs that may be relevant