B-Cell Clonality Screening (IgH and IgK) by PCR
Also known as: BCELL SCRN
Use
This test aids in the diagnosis and monitoring of B-cell lymphoproliferative disorders. It serves as an ancillary test which may be used in conjunction with additional morphologic and clinical evaluation to differentiate between malignant and reactive proliferations. The test utilizes primers from the BIOMED-2 primer set targeting IgH (VHFR1-JH, VHFR2-JH, VHFR3-JH) and IgK (VK-JK, VK-Kde, JKCK intron-Kde) genes to assess B-cell clonality.
Special Instructions
Not provided.
Limitations
The test's limit of detection is approximately 25 percent clonal B-cells in background total B-cells. Results must be interpreted in the context of morphology and other relevant clinical data and should not be used alone for a diagnosis of malignancy.
New York Approved
Methodology
PCR-based
Biomarkers
No genes
Gene
LOINC Codes
- 31208-2 - Specimen source
Result Turnaround Time
5-9 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
1 mL
Container
Lavender (EDTA)
Storage Instructions
Do not freeze
Causes for Rejection
Plasma, serum, specimens in anticoagulants other than EDTA, clotted or grossly hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | 7 days |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant