Comprehensive Systemic Sclerosis Panel
Also known as: SCL COMPRE
Use
The Comprehensive Systemic Sclerosis Panel is used for evaluating systemic sclerosis (SSc), especially when suspicion is high and the patient has features of overlap syndrome. It aids in the diagnosis and helps differentiate SSc from other systemic autoimmune rheumatic diseases such as systemic lupus erythematosus and myositis. The presence of specific antibodies provides insights into the patient's autoimmune profile, which is crucial for diagnosis and management.
Special Instructions
Not provided.
Limitations
The test is not FDA-approved, and its performance characteristics have been determined by ARUP Laboratories in a CLIA-certified laboratory. Negative results do not necessarily rule out systemic sclerosis or the presence of associated antibodies. False-positive results can occur due to non-specific immune complex binding. Clinical correlation with other laboratory and clinical findings is recommended for accurate diagnosis.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 33983-8 - U1 snRNP IgG Ser-aCnc
- 47322-3 - ENA Scl70 IgG Ser IA-aCnc
- 79182-2 - RNAp III IgG SerPl IA-aCnc
- 81732-0 - PM/SCL-100 Ab Ser Ql Line blot
- 49963-2 - Fibrillarin Ab Ser Ql
- 21424-7 - Nuclear IgG Ser Ql IF
- 49311-4 - ANA Pat Ser IF-Imp
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
1.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection.
Storage Instructions
Refrigerated. Also acceptable: Room temperature or frozen.
Causes for Rejection
Hemolyzed, hyperlipemic, icteric, heat-treated or contaminated specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month |
Other tests from different labs that may be relevant