Ganglioside (GM1) Antibodies, IgG and IgM
Also known as: GM1 PAN
Use
Ganglioside antibodies are associated with diverse peripheral neuropathies. Elevated antibody levels to ganglioside-monosialic acid (GM1) are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy. Anti-GM1 antibodies may occur as IgM (polyclonal or monoclonal) or IgG antibodies. These antibodies may also be found in patients with diverse connective tissue diseases as well as normal individuals. These tests by themselves are not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.
Special Instructions
The test is useful when assessing for primarily motor neuron disease and motor neuropathies. It is performed on Tuesdays, Thursdays, and Saturdays, and results are reported within 1-7 days. The test should be used in conjunction with other clinical parameters to confirm disease.
Limitations
The test by itself is not diagnostic and should not be used as the sole basis for diagnosis. Elevated antibodies can also be found in normal individuals and those with diverse connective tissue diseases. The interpretation of the results should be considered in the context of other clinical observations and diagnostic measurements.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 51703-7
- 51729-2
- 51729-2
- 51703-7
Result Turnaround Time
1-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.3 mL
Minimum Volume
0.1 mL
Container
ARUP standard transport tube
Collection Instructions
Collect serum separator tube. Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.3 mL serum to an ARUP standard transport tube.
Storage Instructions
Refrigerate after collection.
Causes for Rejection
Room temperature specimens, plasma, CSF, or other body fluids, contaminated, heat-inactivated, hemolyzed, icteric, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year |