Histoplasma Antibodies by Complement Fixation and Immunodiffusion
Also known as: HISTO PAN
Use
This test aids in the diagnosis of histoplasmosis, a fungal infection caused by Histoplasma capsulatum. Detection of antibodies through complement fixation and immunodiffusion helps in confirming infection. It is recommended to be used in conjunction with Histoplasma Antigen Quantitative by EIA for a comprehensive diagnosis.
Special Instructions
Testing is recommended alongside the Histoplasma Antigen Quantitative by EIA, Serum (0092522) and Histoplasma Galactomannan Antigen Quantitative by EIA, Urine (2009418). Convalescent specimens should be marked plainly and received within 30 days from receipt of acute specimens.
Limitations
A titer of 1:8 or greater may suggest histoplasmosis, but cross-reactions can occur with other fungal diseases, typically at lower titers. This test does not exclude the possibility of an infection even if antibodies are not detected.
New York Approved
Methodology
Immunoassay
Biomarkers
LOINC Codes
- 5218-3
- 20573-2
- 20574-0
Result Turnaround Time
3-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
0.8 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection.
Storage Instructions
Refrigerated
Causes for Rejection
Contaminated, hemolyzed, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year (avoid repeated freeze/thaw cycles) |