Histoplasma Antigen Quantitative by EIA, Serum

Casandra

Casandra Test Code AR57564Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0092522CPT Code 87385

Histoplasma Antigen Quantitative by EIA, Serum

Also known as: HISTOAG S

Clinical Use

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Use

This test aids in the diagnosis of histoplasmosis, an infection caused by the fungus Histoplasma capsulatum. It is particularly useful for detecting the presence of histoplasma antigen in serum, which can indicate an active infection. The test employs a quantitative enzyme immunoassay (EIA) to measure antigen concentrations within the range of 0.19 to 60.0 ng/mL. Results outside this range cannot be accurately quantified. In the context of a positive test, cross-reactivity with other fungi such as Blastomyces dermatitidis, Coccidioides immitis, and possibly Talaromyces marneffei should be considered.

Special Instructions

Testing is not approved for New York state; therefore, specimens from New York clients will be sent to a New York state-approved laboratory. The test should be used in conjunction with other diagnostic procedures such as microbiological culture, histological examination, and serology.

Limitations

Results outside the quantitative range (less than 0.19 ng/mL or greater than 60.0 ng/mL) cannot be accurately quantified. Cross-reactivity with other mycoses, which are endemic in certain geographical regions, may lead to false-positive results. This test should not be the sole basis for diagnosing histoplasmosis and should be used alongside other diagnostic methods.

Test Details