Metabotropic Glutamate Receptor 1 (mGluR1) Antibody, IgG by CBA-IFA With Reflex to Titer, CSF
Also known as: MGLUR1 CSF
Use
Aids in the diagnosis of cerebellar ataxia and limbic encephalitis. May be used to monitor treatment response in individuals who are antibody positive. The presence of mGluR1 antibodies may be associated with subacute cerebellar ataxia, dysgeusia, dysarthria, head titubation, and cognitive impairment. mGluR1 encephalitis may be paraneoplastic; hematologic malignancies are reported in a subset of patients.
Special Instructions
If mGluR1 antibody IgG is positive, then mGluR1 antibody IgG titer will be added. Additional charges apply.
Limitations
A negative test result does not rule out a diagnosis of autoimmune cerebellar ataxia or limbic encephalitis. Interpretation of any antineural antibody test requires clinical correlation.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- 93500-7
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
0.5 mL
Minimum Volume
0.15 mL
Container
ARUP standard transport tube
Collection Instructions
Separate CSF. Transfer to ARUP standard transport tube.
Storage Instructions
Refrigerated.
Causes for Rejection
Grossly hemolyzed or contaminated specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month (Three freeze/thaw cycles are acceptable) |