Anti-N-methyl-D-Aspartate Receptor (NMDAR), Spinal Fluid
Also known as: Autoimmune Dementia Panel Spinal Fluid, Paraneoplastic
Use
NMDAR1 is a glutamate receptor and ion channel found in neurons. This receptor is thought to be very important for controlling synaptic plasticity and mediating learning and memory functions. Antibodies against NMDAR1 generate both neurologic and psychiatric symptoms. Common symptoms include personality change, psychosis, abnormal movements, seizures and autonomic dysfunction. Anti-NMDA receptor IgG antibody is found in a subset of patients with autoimmune limbic encephalitis and may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response; therefore, clinical correlation must be strongly considered. A negative test result does not rule out a diagnosis of autoimmune limbic encephalitis.
Special Instructions
If reflex test is performed, additional charges/CPT code(s) may apply.
Limitations
This test was developed and validated by Labcorp in compliance with CLIA requirements but has not been cleared or approved by the FDA. This should be considered when interpreting results, and additional confirmatory tests should be considered as necessary.
Methodology
Immunoassay
Biomarkers
LOINC Codes
- 82988-7
- 82988-7
Result Turnaround Time
4-6 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
2 mL
Minimum Volume
1 mL
Container
Sterile plastic tube
Storage Instructions
Room temperature
Causes for Rejection
Gross hemolysis; grossly lipemic; gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |