Methylmalonic Acid (MMA) Quantitative, Urine

Also known as: MMA U

Clinical Use

Use

Urinary methylmalonic acid, when increased, is an early and sensitive indicator of vitamin B12 (cobalamin) deficiency. This test can also be used to monitor patients with methylmalonic aciduria. Diagnosis of methylmalonic aciduria requires an organic acid panel and appropriate clinical history. The test helps monitor patients with methylmalonic aciduria by tracking the level of methylmalonic acid in urine, providing important diagnostic and monitoring information for conditions related to methylmalonic acid metabolism.

Special Instructions

Not provided.

Limitations

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. The test is intended for clinical purposes and performed in a CLIA certified laboratory. Interpretation should consider potential fluctuations in urine volume and composition, as well as deviations in collection time or volume, as these can impact the results. It is important to accompany the test with an organic acid panel and appropriate clinical history for accurate diagnosis.

Test Details

New York Approved

Methodology

Mass Spectrometry

Biomarkers

Creatinine

Analyte

Creatinine, Urine - per 24h

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

Methylmalonic Acid

Analyte

MMA - ratio to CRT

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Result Codes

35674-1 - Creat ?Tm Ur-mCnc
2162-6 - Creat 24h Ur-mRate
32287-5 - Methylmalonate Ur-sCnc
25116-5 - Methylmalonate/Creat Ur-sRto
19153-6 - Specimen vol ?Tm Ur
30211-7 - Specimen collect Time Spec
48767-8 - Annotation comment Imp

Result Turnaround Time

1-5 days

Specimen

Urine

Volume

Not provided

Minimum Volume

0.3 mL

Container

ARUP standard transport tube

Collection Instructions

Collect 24-hour or random urine. Transfer a 1 mL aliquot to transport tube and refrigerate or freeze immediately. Record total volume and collection time interval on transport tube and test request form.