Methylmalonic Acid (MMA) Quantitative, Urine
Also known as: MMA U
Use
Urinary methylmalonic acid, when increased, is an early and sensitive indicator of vitamin B12 (cobalamin) deficiency. This test can also be used to monitor patients with methylmalonic aciduria. Diagnosis of methylmalonic aciduria requires an organic acid panel and appropriate clinical history. The test helps monitor patients with methylmalonic aciduria by tracking the level of methylmalonic acid in urine, providing important diagnostic and monitoring information for conditions related to methylmalonic acid metabolism.
Special Instructions
Collect 24-hour or random urine. Refrigerate 24-hour specimens during collection. Transfer a 1 mL aliquot from a well-mixed 24-hour or random urine collection to an ARUP standard transport tube and refrigerate or freeze immediately. Record total volume and collection time interval on transport tube and test request form.
Limitations
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. The test is intended for clinical purposes and performed in a CLIA certified laboratory. Interpretation should consider potential fluctuations in urine volume and composition, as well as deviations in collection time or volume, as these can impact the results. It is important to accompany the test with an organic acid panel and appropriate clinical history for accurate diagnosis.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 35674-1
- 2162-6
- 32287-5
- 25116-5
- 19153-6
- 30211-7
- 48767-8
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
Not provided
Minimum Volume
0.3 mL
Container
ARUP standard transport tube
Collection Instructions
Collect 24-hour or random urine. Transfer a 1 mL aliquot to transport tube and refrigerate or freeze immediately. Record total volume and collection time interval on transport tube and test request form.
Causes for Rejection
Room temperature specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | 1 week |
| Frozen | 1 month |