Methylmalonic Acid, Serum or Plasma (Vitamin B12 Status)

Also known as: MMA QNT-P

Clinical Use

Use

This test is used to evaluate vitamin B12 deficiency in individuals with macrocytic or unexplained anemia, or unexplained neurologic disease. Methylmalonic acid is an intermediate in the metabolism of Vitamin B12; elevated levels may indicate a deficiency in Vitamin B12, leading to conditions like megaloblastic anemia and could also be indicative of renal insufficiency or intravascular volume contraction.

Special Instructions

Not provided.

Limitations

This test's performance characteristics were determined by ARUP Laboratories and it is to be used for clinical purposes, however, this test has not been cleared or approved by the US Food and Drug Administration. It is a Laboratory Developed Test (LDT) and clinicians should interpret the results in context with the patient's medical history and other diagnostic information.

Test Details

New York Approved

Methodology

Mass Spectrometry

Biomarkers

Methylmalonic Acid

Analyte

Methylmalonic Acid, Serum or Plasma

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Order Codes

13964-2 - Methylmalonate SerPl-sCnc

Result Turnaround Time

1-5 days

Specimen

Serum

Volume

1.0 mL

Minimum Volume

0.3 mL

Container

ARUP standard transport tube

Collection Instructions

Centrifuge and remove serum or plasma from cells within 2 hours of collection. Transfer serum or plasma to an ARUP standard transport tube and refrigerate or freeze immediately.