Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by CBA-IFA With Reflex to Titer, CSF
Also known as: MOG CSF
Use
This test may aid in the diagnosis of CNS demyelinating disease, including neuromyelitis optica spectrum disorders such as optic neuritis and transverse myelitis, and autoimmune encephalitis, including brainstem encephalitis and acute disseminated encephalomyelitis. Persistence of antibody positivity might indicate a relapsing course, while decreasing antibody levels may suggest a therapeutic response. A negative result does not exclude a diagnosis of CNS demyelinating disease, and results should be interpreted in the context of clinical history, neurologic exam, imaging, and other laboratory findings. CSF positivity might indicate more severe clinical outcomes.
Special Instructions
If the test is positive, a Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Titer, IgG will be performed, with additional charges. The test uses a cell-based indirect fluorescent antibody assay with full-length MOG transfected cell lines.
Limitations
Serum is the preferred specimen type; however, patients might test positive only in CSF. Low antibody titers may have a lower positive predictive value of disease, necessitating careful interpretation in conjunction with clinical history and other tests. The test has not been cleared or approved by the U.S. Food and Drug Administration but is conducted in a CLIA-certified laboratory for clinical purposes.
New York Approved
Methodology
Immunoassay (Cell-based / Cytometry)
Biomarkers
LOINC Codes
- 91543-9
Result Turnaround Time
1-6 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
0.5 mL
Minimum Volume
0.15 mL
Container
ARUP standard transport tube
Storage Instructions
Refrigerated
Causes for Rejection
Hemolyzed, contaminated specimens, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month |