NMO Spectrum Evaluation (AQP4 with Reflex to MOG), CSF

Casandra

Casandra Test Code QD21831Version 1 (DRAFT)

Performing Lab

Lab Quest DiagnosticsLab Test ID 38313CPT Codes 86052, 86362

NMO Spectrum Evaluation (AQP4 with Reflex to MOG), CSF

Also known as: Transverse Myelitis Antibody, NMO Spectrum Disorder, NMO antibody, Aquaporin, Optic Neuritis Antibody

Clinical Use

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Use

NMO (neuromyelitis optica, Devic disease) is an immune‑mediated chronic inflammatory disease predominantly affecting the optic nerve and spinal cord, presenting with optic neuritis and myelitis. Limited forms—such as isolated optic neuritis, brainstem encephalitis, and longitudinally extensive transverse myelitis (LETM)—are referred to as NMO spectrum disorders (NMOSD). Detection of antibodies against AQP4 or MOG is associated with NMO and NMOSD; AQP4 is evaluated first, with reflex to MOG when appropriate, aiding diagnostic clarity.

Special Instructions

Reflex testing: If AQP4 Antibody, CSF is positive, AQP4 Antibody, Titer, CSF is performed at additional charge (CPT 86052). If AQP4 is negative, MOG Antibody, CBA is performed at additional charge (CPT 86362). If MOG Antibody, CBA is positive, MOG Antibody, Titer, CSF is performed at additional charge (CPT 86362).