p63 by Immunohistochemistry
Also known as: P63 IHC
Use
The p63 by Immunohistochemistry test is used as part of diagnostic procedures in pathology to identify and study specific cellular proteins within tissues or cells. p63, a member of the p53 family, is pivotal in identifying certain types of epithelial cells, thereby aiding in the differentiation of tumors, assessing the origin of malignant cells, and supporting histopathological evaluations. It often plays a significant role in the diagnosis of cancers and helps differentiate squamous cell carcinoma from other neoplasms.
Special Instructions
Submit electronic request for ordering. If electronic ordering is unavailable, use the ARUP Immunohistochemistry Stain Form (#32978) with an ARUP client number. Ensure proper submission procedures to avoid delays: tissue block or slides must be transported with adequate protection against heat. Coordination with ARUP Client Services may be necessary for clarified submission processes.
Limitations
This test is provided solely as a technical service. Interpretive services are not included, and the test results should be correlated with clinical and other diagnostic findings for comprehensive diagnosis. It may not detect small focal areas or all protein expressions, depending on the tissue or cellular context, fixation quality, and other pre-analytical variables. Limitations inherent in immunohistochemistry, such as cross-reactivity, false positives, and variations in staining intensity, may occur.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- 94736-6
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
2 slides
Container
Tissue transport kit (ARUP supply #47808)
Collection Instructions
Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen. Protect paraffin block and/or slides from excessive heat. Transport tissue block or 5 unstained (3- to 5-micron thick sections), positively charged slides.
Storage Instructions
Room temperature or refrigerated. Ship in cooled container during summer months.
Causes for Rejection
Specimens submitted with non-representative tissue type or depleted specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |