Paraneoplastic Pemphigus (Paraneoplastic Autoimmune Multiorgan Syndrome) Screening Antibodies by IIF

Use

Paraneoplastic pemphigus (PNP), also known as paraneoplastic autoimmune multiorgan syndrome (PAMS), is a severe mucocutaneous blistering and erosive disease associated with underlying malignancies, most often hematologic in nature, such as lymphoma and leukemia, and sarcoma. It affects individuals of all ages and can also occur in association with benign neoplasms, like Castleman disease, which is more frequent in children and adolescents. The presence of antibodies targeting various epithelial components can lead to the involvement of multiple organs, such as the eyes, lungs, and gastrointestinal tract, which forms the basis of the multiorgan syndrome. This test is intended to screen for IgG antibodies associated with paraneoplastic pemphigus using indirect immunofluorescence (IIF) on rodent substrates.