Rickettsia typhi (Typhus Fever) Antibody, IgM by IFA
Also known as: TYPHU M
Use
This test is used to confirm the presence of Rickettsia typhi, which is responsible for Typhus Fever. It detects the IgM antibodies through Indirect Fluorescent Antibody (IFA) methodology, helping in the diagnosis of an active or recent infection. IgM reactivity should be interpreted as group-reactive for the Typhus Fever group, which includes Rickettsia prowazekii. The test is ideal for seroconversion studies, with results suggesting recent infection if there is a change in antibody titer between acute and convalescent sera.
Special Instructions
When submitting samples, ensure they are clearly marked as 'acute' or 'convalescent'. Convalescent specimens must be received within 25 days from receipt of the acute specimens. It is preferred if both samples are tested simultaneously at the same facility to compare results directly.
Limitations
Low levels of IgM antibodies may persist for more than 12 months after infection, which might limit the ability to confirm a new infection. Additionally, seroconversion is considered the strongest evidence of recent infection, requiring paired titers to demonstrate significant changes between acute and convalescent phases.
New York Approved
Methodology
Immunoassay (Indirect Fluorescent Antibody (IFA))
Biomarkers
LOINC Codes
- 5325-6
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.4 mL
Container
ARUP standard transport tube
Collection Instructions
Separate from cells ASAP or within 2 hours of collection.
Storage Instructions
Refrigerated.
Causes for Rejection
Contaminated, hemolyzed, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year (avoid repeated freeze/thaw cycles) |